PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial-mesenchymal transition.
Siming YuLinna LiWei TianDan NieWei MuFang QiuYu LiuXinghan LiuXiaofeng WangZhimin DuWen-Feng ChuBaofeng YangPublished in: British journal of pharmacology (2018)
PEP06 is a polypeptide that inhibits the growth and metastasis of colon cancer through its RGD motif binding to integrin αvβ3, thereby down-regulating miR-146b-5p to inhibit EMT in vitro and in vivo. It might have potential as a therapeutic for CRC.