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PIM1 inhibitor SMI-4a attenuated concanavalin A-induced acute hepatitis through suppressing inflammatory responses.

Xinwan WuYuwei ChenMeiru JiangLong Guo
Published in: Translational gastroenterology and hepatology (2024)
In conclusion, the protective effect of SMI-4a against acute hepatitis is by reducing the inflammatory response and apoptosis. These findings suggest that SMI-4a may have therapeutic potential in the treatment of autoimmune hepatitis.
Keyphrases
  • inflammatory response
  • oxidative stress
  • liver failure
  • drug induced
  • multiple sclerosis
  • endoplasmic reticulum stress
  • cell death
  • respiratory failure
  • cell cycle arrest
  • intensive care unit
  • hepatitis b virus