A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp.
Min YangLin-Fu LiangHeng LiWei TangYue-Wei GuoPublished in: Natural product research (2019)
A new 5α,8α-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5α,8α-epidioxy-24-methyl-cholesta-6,24(28)-dien-3β-ol (2) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (3), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1-3 showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μM, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μM.[Formula: see text].
Keyphrases
- induced apoptosis
- cell cycle arrest
- systematic review
- molecular docking
- optical coherence tomography
- electronic health record
- high intensity
- big data
- endoplasmic reticulum stress
- human milk
- peripheral blood
- signaling pathway
- oxidative stress
- cell death
- magnetic resonance imaging
- magnetic resonance
- preterm infants
- data analysis
- mass spectrometry
- low birth weight