The role of miRNAs as a big master regulator of signaling pathways involved in lymphoblastic leukemia.
Malihe BagheriParisa Zia SarabiMahdieh MondanizadehPublished in: Journal of cellular physiology (2022)
MicroRNAs (miRNAs) belong to small noncoding RNAs, which have long attracted researchers' attention because of their potency in acting either as oncogenes or tumor-suppressors in cancers. acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are two known types of leukemia with high mortality rates in adults and children. On a molecular basis, various signaling pathways are active in both types, making researchers consider the potential role of miRNAs in activating or suppressing these pathways to further hinder cancer development. In this review, we summarized the potential miRNAs, especially circulating ones, involved in essential signaling pathways in the ALL and CLL patients which serve as biomarkers and valuable targets in the treatment fields.
Keyphrases
- signaling pathway
- chronic lymphocytic leukemia
- acute myeloid leukemia
- bone marrow
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- newly diagnosed
- young adults
- liver failure
- prognostic factors
- cardiovascular events
- papillary thyroid
- working memory
- cardiovascular disease
- big data
- risk factors
- childhood cancer
- human health
- type diabetes
- coronary artery disease
- cell proliferation
- oxidative stress
- climate change
- replacement therapy
- endoplasmic reticulum stress
- machine learning
- smoking cessation
- artificial intelligence