Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients.
Javad FirouziAbbas HajifathaliMasoumeh AzimiNeda ParviniFatemeh GhaemiNiloufar Shayan AslAmir Abbas Hedayati AslMajid SafaMarzieh EbrahimiPublished in: Cell journal (2023)
We suggested the combination of IL-15 and PD-1 blocker could enhance the killing potential of AMLNK cells. Moreover, Hsp70 in combination with IL-15 and PD-1 blocker interferes activation of AML-NK cells through unknown mechanisms.
Keyphrases
- nk cells
- acute myeloid leukemia
- end stage renal disease
- heat shock protein
- allogeneic hematopoietic stem cell transplantation
- ejection fraction
- angiotensin converting enzyme
- heat stress
- heat shock
- chronic kidney disease
- induced apoptosis
- acute lymphoblastic leukemia
- cell cycle arrest
- multiple myeloma
- patient reported outcomes
- signaling pathway
- hodgkin lymphoma
- human health
- patient reported