Molecular Mechanism of the Effect of Zhizhu Pill on Gastroesophageal Reflux Disease Based on Network Pharmacology and Molecular Docking.

Jinke Huang Yitian Wang Peng Xu Jiali Liu Jinxin Ma Yu Wang Zhihong Liu Mi Lv Feng-Yun Wang Xu-Dong Tang

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

The results of this study predict that the therapeutic effects of ZZP in GERD are mediated at least in part via PPARG, MMP9, JUN, TP53, PTGS2, EGFR, MAPK3, CASP3, AKT1, and VEGFA. These results may be useful in providing an experimental basis and new ideas for further research on ZZP in GERD.

Keyphrases

gastroesophageal reflux disease
molecular docking
signaling pathway
small cell lung cancer
molecular dynamics simulations
epidermal growth factor receptor
tyrosine kinase
cell proliferation
oxidative stress
pi k akt