Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification.

Kristi LällMaarja LepametsMarili PaloverTõnu EskoAndres MetspaluNeeme TõnissonPeeter PadrikReedik MägiKrista Fischer

Published in: BMC cancer (2019)

We have shown that metaGRS2, that combined on the effects of more than 900 SNPs, provided best predictive ability for breast cancer in two different population-based cohorts. The strength of the effect of metaGRS2 indicates that the GRS could potentially be used to develop more efficient strategies for breast cancer screening for genotyped women.

Keyphrases

genome wide
breast cancer risk
polycystic ovary syndrome
gene expression
metabolic syndrome
dna methylation
insulin resistance
copy number
cervical cancer screening
childhood cancer