DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.
Maria KellerAnat Yaskolka MeirStephan H BernhartYftach GepnerIlan ShelefDan SchwarzfuchsGal TsabanHila ZelichaLydia HoppLuise MüllerKerstin RohdeYvonne BöttcherPeter F StadlerMichael StumvollMatthias BlüherPeter KovacsIris ShaiPublished in: Genome medicine (2020)
Body weight-loss following 18-month lifestyle intervention is associated with specific methylation signatures. Moreover, methylation differences in the identified genes could serve as prognostic biomarkers to predict a successful weight-loss therapy and thus contribute to advances in patient-tailored obesity treatment.
Keyphrases
- weight loss
- genome wide
- dna methylation
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- glycemic control
- gene expression
- weight gain
- physical activity
- copy number
- clinical trial
- study protocol
- metabolic syndrome
- phase ii
- type diabetes
- cardiovascular disease
- stem cells
- mesenchymal stem cells
- skeletal muscle
- transcription factor
- genome wide identification
- high fat diet induced