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DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.

Maria KellerAnat Yaskolka MeirStephan H BernhartYftach GepnerIlan ShelefDan SchwarzfuchsGal TsabanHila ZelichaLydia HoppLuise MüllerKerstin RohdeYvonne BöttcherPeter F StadlerMichael StumvollMatthias BlüherPeter KovacsIris Shai
Published in: Genome medicine (2020)
Body weight-loss following 18-month lifestyle intervention is associated with specific methylation signatures. Moreover, methylation differences in the identified genes could serve as prognostic biomarkers to predict a successful weight-loss therapy and thus contribute to advances in patient-tailored obesity treatment.
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