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Cutaneous metastases of papillary renal cell carcinoma: A case report and review of the literature.

Leah A CardwellNicole R BenderOlayemi Sokumbi
Published in: Journal of cutaneous pathology (2019)
Papillary renal cell carcinoma (RCC) is an uncommon subtype of RCC that is typically encountered at early stages and has a high survival rate. Histopathology typically shows well-defined papillary architecture with tumor cells lining fibrovascular cores and can be further subdivided into type 1 and type 2 tumors based on cytology and genetic basis. Type 1 tumors have a single layer of basophilic cells and low nuclear atypia, while type 2 tumors have a pseudostratified layer of eosinophilic cells and high nuclear atypia. Some tumors have overlapping features of both types. We present a unique case of cutaneous metastases of papillary RCC with typical papillary architecture in the dermis and review the literature on this rare entity.
Keyphrases
  • renal cell carcinoma
  • clear cell
  • induced apoptosis
  • cell cycle arrest
  • systematic review
  • oxidative stress
  • cell death
  • cell proliferation
  • genome wide