The prognostic significance of CDKN2A homozygous deletion in IDH-mutant lower-grade glioma and glioblastoma: a systematic review of the contemporary literature.

Victor M LuKyle P O'ConnorAshish H ShahDaniel G EichbergEvan M LutherRicardo J KomotarMichael E Ivan

Published in: Journal of neuro-oncology (2020)

The CDKN2A homozygous deletion is an important prognostic factor for survival outcomes of IDH-mutant glioma patients across multiple histologic WHO grades with specific molecular features likely dependent on IDH-mutant status. Greater understanding of how identifying this deletion can assist in the stratification of management for these tumors to optimize clinical course is required.

Keyphrases

wild type
prognostic factors
low grade
end stage renal disease
ejection fraction
systematic review
chronic kidney disease
newly diagnosed
peritoneal dialysis
patient reported outcomes
single molecule