Examining the causal mediating role of cardiovascular disease on the effect of subclinical cardiovascular disease on cognitive impairment via separable effects.
Ryan M AndrewsIlya ShpitserVanessa DidelezPaulo H M ChavesOscar L LopezMichelle C CarlsonPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
We found that the effect of sCVD on cognitive impairment does not seem to be mediated by CVD, both overall and within APOE-4 subgroups. Our results were critically assessed via sensitivity analyses, and they were found to be robust. Future work is needed to fully understand the relationship between sCVD, CVD, and cognitive impairment.