Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.
Natàlia Vilor-TejedorIacopo CiampaGrégory OpertoCarles FalcónMarc Suárez-CalvetMarta Crous-BouMahnaz ShekariEider M Arenaza-UrquijoMarta Milà-AlomàOriol Grau-RiveraCarolina MinguillonGwendlyn KollmorgenHenrik ZetterbergKaj BlennowRoderic GuigoJosé Luis L MolinuevoJuan-Domingo Gispertnull nullPublished in: Alzheimer's research & therapy (2021)
Our results support that ePVS in the CS are specifically associated with tau pathophysiology, neurodegeneration, and synaptic dysfunction in asymptomatic stages of the Alzheimer's continuum.