Fibrosis, biomarkers and liver biopsy in AAT deficiency and relation to liver Z protein polymer accumulation.
Anandini SuriZidong ZhangBrent Neuschwander-TetriDavid A LomasNina Heyer-ChauhanKeith BurlingRohit LoombaDavid A BrennerRosemary NagyAndrew WilsonDanielle CarpenterKeith BlomenkampJeffrey H TeckmanPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
In AATD high BMI, obesity and elevated AST are associated with increased fibrosis. Liver biopsy features are correlated to some serum tests. Serum Z AAT polymer levels could be a future biomarker to detect fibrosis early and is directly correlated to liver Z content.