Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction.
Daniela Miranda-SilvaRob C I WüstGlória ConceiçãoPatrícia Gonçalves-RodriguesNádia GonçalvesAlexandre GonçalvesDiederik W D KusterAdelino F Leite-MoreiraJolanda van der VeldenJorge M de Sousa BelezaJosé MagalhãesGer J M StienenInês Falcão-PiresPublished in: Acta physiologica (Oxford, England) (2019)
The free mitochondrial calcium concentration is higher in HFpEF owing to alterations in mitochondrial and cytosolic Ca2+ handling. This coupling between cytosolic and mitochondrial Ca2+ levels may compensate for myocardial ATP supply in vivo under conditions of mild mitochondrial dysfunction. However, if mitochondrial Ca2+ concentration is sustainedly increased, it might trigger mitochondrial permeability transition pore opening.