Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases.

Annie YangZhifang ZhangShyambabu ChaurasiyaAnthony K ParkAudrey JungJianming LuSang-In KimSaul J PricemanYuman FongYanghee Woo

Published in: Journal for immunotherapy of cancer (2023)

Our results show that CF33-OVs can deliver functional proteins and demonstrate effective antitumor activity in GCPM models when delivered intraperitoneally. These preclinical results will inform the design of future peritoneal-directed therapy in GCPM patients.

Keyphrases

cystic fibrosis
end stage renal disease
chronic kidney disease
ejection fraction
prognostic factors
mesenchymal stem cells
stem cells
peritoneal dialysis
cell therapy
replacement therapy
current status