Important and specific role for basophils in acute allergic reactions.
Peter KorosecB F GibbsM RijavecA CustovicP J TurnerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.
Keyphrases
- allergic rhinitis
- chronic obstructive pulmonary disease
- liver failure
- respiratory failure
- lung function
- dendritic cells
- induced apoptosis
- regulatory t cells
- drug induced
- single cell
- aortic dissection
- cell therapy
- cell cycle arrest
- oxidative stress
- stem cells
- physical activity
- signaling pathway
- air pollution
- extracorporeal membrane oxygenation
- human health
- climate change