SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation.

Xiao XuXiaojie DengYunzhi ChenWen XuFen XuHua Liang

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2022)

We first preliminarily revealed SIRT1 may regulate PNPLA3 gene expression by affecting SREBP-1-driven transcription via acetylation modification of H3K9.

Keyphrases

gene expression
transcription factor
oxidative stress
ischemia reperfusion injury
histone deacetylase
dna methylation
single cell