A Subset of SMARCB1 (INI-1)-deficient vulvar neoplasms express germ cell markers.

Phoebe M HammerDavid L KolinGregory W Charville W Glenn McCluggage Brooke E Howitt

Published in: Histopathology (2022)

Our study reveals that SALL4, glypican-3, and OCT3/4 are positive in a subset of SMARCB1-deficient vulvar neoplasms, which may pose a diagnostic challenge and result in consideration of a germ cell tumour. We also highlight a case with transition from ES to YST-like morphology, lending further support that YSTs of the vulva are somatically derived SMARCB1-deficient neoplasms and do not represent true germ-cell neoplasia.

Keyphrases

germ cell
sentinel lymph node

wild type
high grade

optical coherence tomography
early stage

lymph node