A review of single-cell transcriptomics and epigenomics studies in maternal and child health.
Chang ShuKelly StreetCarrie V BretonTheresa M BastainMelissa L WilsonPublished in: Epigenomics (2024)
Single-cell sequencing technologies enhance our understanding of cellular dynamics throughout pregnancy. We outlined the workflow of single-cell sequencing techniques and reviewed single-cell studies in maternal and child health. We conducted a literature review of single cell studies on maternal and child health using PubMed. We summarized the findings from 16 single-cell atlases of the human and mammalian placenta across gestational stages and 31 single-cell studies on maternal exposures and complications including infection, obesity, diet, gestational diabetes, pre-eclampsia, environmental exposure and preterm birth. Single-cell studies provides insights on novel cell types in placenta and cell type-specific marks associated with maternal exposures and complications.
Keyphrases
- single cell
- rna seq
- pregnancy outcomes
- preterm birth
- high throughput
- birth weight
- case control
- weight gain
- gestational age
- type diabetes
- weight loss
- endothelial cells
- physical activity
- low birth weight
- insulin resistance
- risk factors
- mesenchymal stem cells
- preterm infants
- risk assessment
- induced pluripotent stem cells