Access to CF 2 COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N -Cyanamide Alkenes.

A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N -cyanamide alkenes has been developed. A variety of CF 2 COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.