Improvement effects of a novel Chinese herbal formula in imiquimod and IL-23-stimulated mouse models of psoriasis.
Lan WangYao-Xing DouQiu-Xia YuZhen HuSiu-Po IpYan-Fang XianZhi-Xiu LinPublished in: Chinese medicine (2024)
ISDF has a strong anti-psoriatic therapeutic effect on mouse models induced with psoriasis through IMQ and IL-23, which is achieved by inhibiting the activation of the Jak/Stat3-activated IL-23/Th17 axis and the downstream NF-κB signalling and MAPK signalling pathways. ISDF holds great potential to be a therapy for psoriasis and should be further developed for this purpose.
Keyphrases
- signaling pathway
- mouse model
- oxidative stress
- pi k akt
- rheumatoid arthritis
- atopic dermatitis
- diabetic rats
- high glucose
- lps induced
- systemic lupus erythematosus
- disease activity
- immune response
- human milk
- nuclear factor
- risk assessment
- preterm infants
- endothelial cells
- toll like receptor
- preterm birth
- low birth weight