Clinical and radiological correlates of apathy in multiple sclerosis.

Francesco TazzaSimona SchiaviElisa LeveraroMaria CellerinoGiacomo BoffaStefania BalleriniMara DigheroAntonio Uccelli Elvira Sbragia Kenda AluanMatilde IngleseCaterina Lapucci

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)

Apathy in PwMS is associated with higher levels of physical disability, depression, anxiety and fatigue together with lower educational backgrounds. Microstructural damage within frontal cortex, caudate and fronto-striatal WM bundles is a significant pathological substrate of apathy in multiple sclerosis (MS).

Keyphrases

multiple sclerosis
white matter
functional connectivity
sleep quality
physical activity
depressive symptoms
oxidative stress
mental health
working memory
parkinson disease
mass spectrometry
structural basis
deep brain stimulation