MicroRNAs Associated with Incident Diabetes in the Diabetes Prevention Program.

Elena FlowersBradley E AouizeratAlka M KanayaJose C FlorezXingyue GongLi Zhang

Published in: The Journal of clinical endocrinology and metabolism (2022)

We identified five miRs that are optimal predictors of incident T2D in the DPP cohort. Future directions include validation of this finding in an independent sample in order to determine whether this risk score may have potential clinical utility for risk stratification of individuals with prediabetes, and functional analysis of the potential genes and pathways targeted by the miRs that were included in the risk score.

Keyphrases

cardiovascular disease
type diabetes
glycemic control
human health
quality improvement
genome wide
risk assessment
gene expression
metabolic syndrome
drug delivery
dna methylation
transcription factor