Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal.
Joseph W JacksonJames S FosterEmily B MartinSallie MacyCraig WooliverManasi BalachandranTina RicheyR Eric HeidelAngela D WilliamsStephen J KennelJonathan S WallPublished in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)
These data suggest that amyloid-associated collagen serves as a 'don't eat me' signal, thereby hindering clearance of amyloid. Targeted degradation of amyloid-associated collagen could result in innate immune cell recognition and clearance of pathologic amyloid deposits.Abbreviationsr: AL: Immunoglobulin light chain amyloidosis; ANOVA: Analysis of variance; ApoE: Apolipoprotein E; ATTR: Transthyretin amyloidosis; ATTRv: Hereditary transthyretin amyloidosis; ATTRwt: Wildtype transthyretin amyloidosis; BSA: Bovine serum albumin; DL800: Dylight 800; H&E: Haematoxylin and eosin; IHC: Immunohistochemistry; LPS: Lipopolysaccharide; MRD: Mean raw density; NU/NU mice: Athymic nude mouse; PMA: Phorbolmyristate acetate; ROI: Region of interest.