Clopidogrel drug interactions: a review of the evidence and clinical implications.
Chang Hoon LeeFrancesco FranchiDominick J AngiolilloPublished in: Expert opinion on drug metabolism & toxicology (2020)
Clopidogrel-drug interactions are common. Most of these DDIs are limited to laboratory findings showing an impact on clopidogrel-induced antiplatelet effects. While variability in clopidogrel-induced antiplatelet effects is known to affect clinical outcomes, with high platelet reactivity being associated with thrombotic complications among patients undergoing coronary stenting, most studies assessing the clinical implications of clopidogrel-drug interactions have not shown to significantly affect outcomes. However, awareness of these DDIs remains important for optimizing the selection of concomitant therapies.
Keyphrases
- acute coronary syndrome
- antiplatelet therapy
- percutaneous coronary intervention
- patients undergoing
- coronary artery disease
- high glucose
- diabetic rats
- coronary artery
- drug induced
- type diabetes
- heart failure
- skeletal muscle
- atrial fibrillation
- insulin resistance
- transcatheter aortic valve replacement
- aortic stenosis