Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction.
Carlos G Santos-GallegoJuan Antonio Requena-IbáñezBelen PicatosteBrian FardmanKiyotake IshikawaRenata MazurekMichael PieperSamantha SartoriJorge Rodríguez-CapitánValentin FusterJuan José BadimonPublished in: Circulation. Cardiovascular imaging (2023)
One-week pretreatment with empagliflozin ameliorates ischemia reperfusion injury, reduces MI size and microvascular obstruction, increases myocardial salvage, preserves left ventricle systolic function, and lowers apoptosis and oxidative stress. Periprocedural intravenous infusion of BOHB during myocardial ischemia also induces cardioprotection, suggesting a role for BOHB availability as an additional mechanism within the wide spectrum of actions of SGLT2i.
Keyphrases
- oxidative stress
- left ventricular
- ischemia reperfusion injury
- acute myocardial infarction
- mitral valve
- percutaneous coronary intervention
- heart failure
- induced apoptosis
- dna damage
- diabetic rats
- low dose
- pulmonary hypertension
- blood pressure
- high dose
- pulmonary artery
- endoplasmic reticulum stress
- cell cycle arrest
- cell death
- coronary artery disease
- congenital heart disease
- cell proliferation
- signaling pathway
- atrial fibrillation