Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy.

Manuel WeißenbergerMike WagenbrennerJoachim NickelRasmus AhlbrechtTorsten BlunkAndre F SteinertFabian Gilbert

Published in: Journal of experimental orthopaedics (2023)

R57A is a stronger inducer of chondrogenesis in BMSCs than the GDF-5 wild type while leading to lower levels of chondrogenic hypertrophy in comparison with TGF-ß1.

Keyphrases

mesenchymal stem cells
wild type
bone marrow
transforming growth factor
smoking cessation