Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis.

Seth A SharpStephen S RichAndrew R WoodSamuel E JonesRobin N BeaumontJames W HarrisonDarius A SchneiderJonathan M LockeJess TyrrellMichael N WeedonWilliam A HagopianRichard D Oram

Published in: Diabetes care (2019)

An improved T1D GRS, the T1D GRS2, is highly useful for classifying adult incident diabetes type and improving newborn screening. Given the cost-effectiveness of SNP genotyping, this approach has great clinical and research potential in T1D.

Keyphrases

type diabetes
cardiovascular disease
genome wide
glycemic control
dna methylation
high throughput
copy number
genetic diversity
metabolic syndrome
adipose tissue
skeletal muscle
young adults