The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.
Aniruddha Kishandutt AgarwalRupesh AgrawalDinesh Visva GunasekaranDhananjay RajeBhaskar GuptaKanika AggarwalSomasheila L MurthyMark WestcottSoon Phaik CheePeter McCluskeyHo Su LingStephen TeohCimino LucaJyotirmay BiswasShishir NarainPadmamalini MahendradasMoncef KhairallahNicholas JonesIlknur Tugal-TutkunKalpana BabuSoumayava BasuEster CarreñoRichard LeeHassan Al-DhibiBahram BodaghiAlessandro InvernizziDebra A GoldsteinCarl P HerbortTalin Barisani-AsenbauerJulio J González-LópezSofia AndroudiReema BansalBruttendu MoharanaSarakshi MahajanSimona EspostiAnastasia TasiopoulouSengal NadarajahSharanya AbrahamRuchi ValaRamandeep SinghAman SharmaKusum SharmaManfred ZierhutOnn Min KonEmmett CunninghamQuan Dong NguyenCarlos PavesioVishali GuptaPublished in: Ocular immunology and inflammation (2017)
Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.
Keyphrases
- mycobacterium tuberculosis
- real time pcr
- end stage renal disease
- patients undergoing
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- emergency department
- rheumatoid arthritis
- cell therapy
- quality improvement
- electronic health record
- human immunodeficiency virus
- hiv aids
- bone marrow
- adverse drug
- hiv infected