The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.

Hao-Yu ChuangLi-Yun HsuChih-Ming Pan Vijesh Kumar YadavIat-Hang FongChao-Hsuan ChenChi-Tai YehShao-Chih Chiu

Published in: International journal of molecular sciences (2021)

These findings demonstrate the critical role of NEDD4-1 in regulating the redox imbalance in TMZ-resistant GBM cells via the degradation of PTEN and the upregulation of the AKT/NRF2/HO-1 signaling pathway. Targeting this regulatory axis may help eliminate TMZ-resistant glioblastoma.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
induced apoptosis
cell proliferation
oxidative stress
epithelial mesenchymal transition
drug delivery
endoplasmic reticulum stress
long non coding rna
electron transfer