Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux.
Bo NiXuan HeYeqian ZhangZeyu WangZhongyi DongXiang XiaGang ZhaoHui CaoChunchao ZhuQing LiJiahua LiuHuimin ChenZizhen ZhangPublished in: Cellular oncology (Dordrecht) (2023)
From our data we conclude that TAMs, homing around metastatic nests, induce the autophagy flux of GC cells and promote the development of liver metastasis via GDNF-GFRA1 signalling. This is expected to improve the comprehension of metastatic pathogenesis and to provide a novel direction of research and translational strategies for the treatment of metastatic GC patients.
Keyphrases
- squamous cell carcinoma
- small cell lung cancer
- end stage renal disease
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- signaling pathway
- ejection fraction
- oxidative stress
- newly diagnosed
- chronic kidney disease
- cell cycle arrest
- peritoneal dialysis
- prognostic factors
- adipose tissue
- electronic health record
- pi k akt
- patient reported
- smoking cessation