Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-KCa2.3 signaling complex.

Junhao HuangHai ZhangXianming TanMin HuBing Shen

Published in: Clinical interventions in aging (2019)

These results suggest an important role for the TRPV4-KCa2.3 signaling undergirding the beneficial effect of exercise to ameliorate age-related arterial dysfunction.

Keyphrases

high intensity
oxidative stress
physical activity
neuropathic pain
resistance training
nitric oxide
aortic valve
pulmonary artery
heart failure
coronary artery
body composition
pulmonary hypertension