Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS.
Miho ShimizuKengo FuruichiTadashi ToyamaTomoaki FunamotoShinji KitajimaAkinori HaraDaisuke OgawaDaisuke KoyaKenzo IkedaYoshitaka KoshinoYukie KurokawaHideharu AbeKiyoshi MoriMasaaki NakayamaYoshio KonishiKen-Ichi SamejimaMasaru MatsuiHiroyuki YamauchiTomohito GohdaKei FukamiDaisuke NagataHidenori YamazakiYukio YuzawaYoshiki SuzukiShouichi FujimotoShoichi MaruyamaSawako KatoTakero NaitoKenichi YoshimuraHitoshi YokoyamaTakashi Wadanull nullPublished in: Clinical and experimental nephrology (2017)
These results suggest that a ≥30% decline in eGFR over 1 or 2 years adds prognostic information about risk for ESRD in patients with type 2 diabetes and macroalbuminuria, supporting the consideration of percentage decline in eGFR as a surrogate endpoint among macroalbuminuric cases in type 2 diabetes. On the other hand, our study suggests that additional analyses on the relationship between remission of macroalbuminuria and risk of ESRD are needed in type 2 diabetes.