Development of a model of Saint Louis encephalitis infection and disease in mice.

Rafael Elias MarquesJuliana L Del SartoRebeca P F RochaGiovanni F GomesAllysson CramerMilene A RachidDanielle G SouzaMaurício L NogueiraMauro M Teixeira

Published in: Journal of neuroinflammation (2017)

Altogether, intracranial SLEV infection leads to meningoencephalitis in mice, recapitulating several aspects of St. Louis encephalitis in humans. Our study indicates that the central nervous system (CNS) inflammation is a major component of SLEV-induced disease. This model may be useful to identify mechanisms of disease pathogenesis or resistance to SLEV infection.

Keyphrases

oxidative stress
high fat diet induced
type diabetes
high glucose
diabetic rats
skeletal muscle
cerebrospinal fluid
stress induced