Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499.
Haruki AzamiYoshihiro WatanabeKazunari SakaiHiroki NakaharaHiroki KojimaToshiyuki TokiwaKenichi NonakaYoshihiko NoguchiYuriko NaganoTomoyasu HiroseToshiaki SunazukaHidehito MatsuiNaoaki ArimaKazutoyo AbeHideaki HanakiMasato IwatsukiPublished in: The Journal of antibiotics (2024)
A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity against clinically isolated Candida auris strains, with MIC values ranging from 0.0625 to 4 µg ml -1 .
Keyphrases
- candida albicans
- ms ms
- biofilm formation
- mass spectrometry
- escherichia coli
- multiple sclerosis
- heavy metals
- high resolution
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- liquid chromatography
- endothelial cells
- cell wall
- gas chromatography mass spectrometry
- gas chromatography
- simultaneous determination
- solid state
- tandem mass spectrometry
- polycyclic aromatic hydrocarbons
- anti inflammatory
- organic matter
- high resolution mass spectrometry