Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation.
Zhenming WangJin ZhaoWanze TangLiqiu HuXin ChenYiping SuChang ZouJianhong WangWilliam W LuWanxin ZhenRonghua ZhangDazhi YangSonglin PengPublished in: Small (Weinheim an der Bergstrasse, Germany) (2019)
Tissue-engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone-tissue regeneration.
Keyphrases
- extracellular matrix
- drug delivery
- hyaluronic acid
- wound healing
- drug release
- tissue engineering
- bone regeneration
- stem cells
- metal organic framework
- reduced graphene oxide
- quantum dots
- highly efficient
- cancer therapy
- mesenchymal stem cells
- bone marrow
- machine learning
- bone mineral density
- big data
- gold nanoparticles
- endothelial cells
- diabetic rats
- heavy metals
- electronic health record
- oxidative stress
- postmenopausal women
- body composition
- artificial intelligence