Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe.
Mona AhmedTetyana TegnebrattThuy A TranLi LuPeter DambergAnton GisteråLaura TarnawskiDianna BoneUlf HedinPer ErikssonStaffan HolminBjörn GustafssonKenneth CaidahlPublished in: International journal of nanomedicine (2020)
89Zr radiolabeling of Mal-HSA probes resulted in detectable activity in atherosclerotic lesions in aortas of Apoe-/- mice, as demonstrated by quantitative in vivo PET/MRI. 89Zr-Mal-HSA appears to be a promising diagnostic tool for the early identification of macrophage-rich areas of inflammation in atherosclerosis.
Keyphrases
- pet imaging
- mouse model
- oxidative stress
- cardiovascular disease
- living cells
- magnetic resonance imaging
- positron emission tomography
- small molecule
- adipose tissue
- high fat diet
- high resolution
- single molecule
- high fat diet induced
- type diabetes
- diffusion weighted imaging
- insulin resistance
- skeletal muscle
- fluorescent probe
- mass spectrometry
- bioinformatics analysis