Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus.
Aline G J EngbersRobert B FlintSwantje VöllerJohan C A de KlerkIrwin K M ReissPeter AndriessenKian D LiemPieter L J DegraeuweSiska CroubelsJoske MillecamKarel AllegaertSinno H P SimonsCatherijne A J KnibbePublished in: British journal of clinical pharmacology (2020)
S-ibuprofen clearance shows important maturation, especially with PNA, resulting in an up to 3-fold increase in CLS during a 3-day treatment regimen. This rapid increase in clearance needs to be incorporated in dosing guidelines by adjusting the dose for every day after birth to achieve equal ibuprofen exposure.