TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity.

Amira M Badr Layla A Alkharashi Hala A Attia Samiyah AlshehriHanaa N AlajamiRehab A AliYasmen F Mahran

Published in: Pharmaceuticals (Basel, Switzerland) (2023)

This study emphasizes that inhibition of TLR4/NLPR3/IL-1β/GSDMD might be a novel mechanism of the nephroprotective effects of NAC or CGA against Cp-induced nephrotoxicity in rats.

Keyphrases

toll like receptor
inflammatory response
drug induced
immune response
transcription factor
high glucose
nuclear factor
diabetic rats
fluorescent probe