PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Yixu JiangFeilin LiuFei ZouYingyao ZhangBo WangYuying ZhangAobo LianXing HanZinan LiuXiaomei LiuMinghua JinDianliang WangGang LiJin Yu LiuPublished in: Stem cell research & therapy (2019)
PBX1 enhanced HF-MSC proliferation, and HF-MSCs induced pluripotent stem cells (iPSC) generation by activating the AKT/GSK3β signaling pathway. During the reprogramming of HF-MSCs into HF-iPSCs, PBX1 activated the NANOG promoter, upregulated NANOG, and inhibited mitochondrion-mediated apoptosis via the AKT/GSK3β pathway during the early stages of reprogramming.
Keyphrases
- signaling pathway
- induced pluripotent stem cells
- pi k akt
- cell cycle arrest
- cell proliferation
- acute heart failure
- induced apoptosis
- epithelial mesenchymal transition
- mesenchymal stem cells
- gene expression
- oxidative stress
- dna methylation
- umbilical cord
- cell death
- bone marrow
- transcription factor
- heart failure
- cell cycle
- protein kinase