Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
Bernard La ScolaMarion Le BideauJulien AndreaniVan Thuan HoangClio GrimaldierPhilippe ColsonPhilippe GautretDidier RaoultPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2020)
In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- end stage renal disease
- infectious diseases
- computed tomography
- newly diagnosed
- healthcare
- image quality
- dual energy
- ejection fraction
- chronic kidney disease
- contrast enhanced
- case report
- peritoneal dialysis
- positron emission tomography
- prognostic factors
- copy number
- genome wide
- drug delivery
- patient reported
- mass spectrometry
- acute care
- double blind
- transcription factor
- pain management