Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.
Jason G E ZeltVirgilio CadeteYupu DengRafael GodoyAlexanne CuillerierKatelynn RoweMohammad Abdul-GhaniLynn MegeneyYan BurelleAntonio GiuliviAlexandre F R StewartSteeve ProvencherSandra Breuils-BonnetSebastien BonnetRobert A deKempRob BeanlandsLisa M MielniczukDuncan J StewartPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Therefore, Fischer rats exhibit profound AK1 deficiency and inefficient cardiac energetics likely related to reduced adenosine triphosphate shuttling from the mitochondria to the contractile fibers. This represents a novel mechanism for RV failure in response to chronic increases in afterload.