5-Fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker.

Francesco AlessandrinoLei QinGisele CruzSonia SahuMichael H RosenthalJeffrey A MeyerhardtAtul B Shinagare

Published in: Abdominal radiology (New York) (2020)

This proof-of-concept study shows that there are early changes in liver texture on first follow-up CT in patients with LFT elevation during 5-FU-based chemotherapy for colorectal cancer. In more than 50% of cases, these changes occur before LFT elevation becomes evident on blood tests.

Keyphrases

contrast enhanced
computed tomography
dual energy
magnetic resonance imaging
positron emission tomography
image quality
high glucose
magnetic resonance
diabetic rats
oxidative stress
drug induced
endothelial cells
squamous cell carcinoma
radiation therapy
chemotherapy induced