5-Fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker.
Francesco AlessandrinoLei QinGisele CruzSonia SahuMichael H RosenthalJeffrey A MeyerhardtAtul B ShinagarePublished in: Abdominal radiology (New York) (2020)
This proof-of-concept study shows that there are early changes in liver texture on first follow-up CT in patients with LFT elevation during 5-FU-based chemotherapy for colorectal cancer. In more than 50% of cases, these changes occur before LFT elevation becomes evident on blood tests.