Monitoring PSMA Responses to ADT in Prostate Cancer Patient-Derived Xenograft Mouse Models Using [18F]DCFPyL PET Imaging.
Jyoti RoyMargaret E WhiteFalguni BasuliAna Christina L OpinaKaren WongMorgan RibaAnita T TonXiang ZhangKeith H JanssonElijah EdmondsonDonna ButcherFrank I LinPeter L ChoykeKathleen KellyElaine M JagodaPublished in: Molecular imaging and biology (2021)
Tumor responses to ADT varied from sensitive to resistant among these LuCaP PDXs, while only the high PSMA expressing LuCaP model exhibited an increase in PSMA levels in response to ADT. These models may be useful in understanding the clinical relevance of PSMA PET responses to ADT and potentially the relationship to disease progression as it may relate to the genomic signature.