Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort.
Rhian S ConveryMartina BocchettaCaroline V GreavesKatrina M MooreDavid M CashJohn Cornelis van SwietenFermin MorenoRaquel Sánchez-ValleBarbara BorroniRobert LaforceMario MasellisMaria Carmela TartagliaCaroline GraffDaniela GalimbertiJames Benedict RoweElizabeth C FingerMatthis SynofzikRik VandenbergheAlexandre de MendoncaFabrizio TagliaviniIsabel SantanaSimon DucharmeChristopher ButlerAlex GerhardJohannes LevinAdrian DanekMarkus OttoJason D WarrenJonathan Daniel Rohrernull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
Changes in pain perception are a feature of C9orf72 expansion carriers, likely representing a disruption in somatosensory, homeostatic and semantic processing, underpinned by atrophy in a thalamo-cortico-striatal network.