The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging.
Xiaoxia YeMingming MoSimin XuQingjin YangMinhua WuJunjie ZhangBin ChenJian LiYu ZhongQionglin HuangChun CaiPublished in: BMC cancer (2018)
The p16 gene body was remarkably hyper-methylated in CRC tissues and associated with p16 protein expression and cancer clinicopathological staging. The combination of p16 exon 1 and exon 2 could better reflect the overall methylation status of p16 gene body and provide potential biomarkers of CRC.