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The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging.

Xiaoxia YeMingming MoSimin XuQingjin YangMinhua WuJunjie ZhangBin ChenJian LiYu ZhongQionglin HuangChun Cai
Published in: BMC cancer (2018)
The p16 gene body was remarkably hyper-methylated in CRC tissues and associated with p16 protein expression and cancer clinicopathological staging. The combination of p16 exon 1 and exon 2 could better reflect the overall methylation status of p16 gene body and provide potential biomarkers of CRC.
Keyphrases
  • genome wide
  • papillary thyroid
  • copy number
  • lymph node
  • squamous cell
  • genome wide identification
  • gene expression
  • dna methylation
  • pet ct
  • lymph node metastasis
  • young adults