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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model.

Min Kyu Mark KimMatthew LawrenceDiana QuinonezCourtney BrooksRithwik RamachandranCheryle A Séguin
Published in: Osteoarthritis and cartilage (2024)
These studies suggest a role for Trpv4 in regulating extracellular matrix synthesis and mediating the response of IVD tissues to mechanical stress.
Keyphrases
  • extracellular matrix
  • mouse model
  • high glucose
  • diabetic rats
  • gene expression
  • drug induced
  • case control
  • human health
  • stress induced
  • oxidative stress
  • risk assessment
  • binding protein
  • climate change
  • brain injury