Lipoprotein(a) plasma levels are not associated with incident microvascular complications in type 2 diabetes mellitus.

Sunny S SinghMardin RashidAloysius G LieverseFlorian KronenbergClaudia LaminaMonique T MulderYolanda B de RijkeEric J G SijbrandsMandy van Hoek

Published in: Diabetologia (2020)

Our data show no association between Lp(a) plasma levels and the LPA SNPs with known effect on Lp(a) plasma levels with the development of microvascular complications in type 2 diabetes. This indicates that Lp(a) does not play a major role in the development of microvascular complications. However, larger studies are needed to exclude minimal effects of Lp(a) on the development of microvascular complications.

Keyphrases

type diabetes
risk factors
cardiovascular disease
gene expression
electronic health record
adipose tissue
insulin resistance
machine learning
deep learning
artificial intelligence