Selenium Supplementation Improved Cardiac Functions by Suppressing DNMT2-Mediated GPX1 Promoter DNA Methylation in AGE-Induced Heart Failure.

Huolan Zhu Xiang Wang Xuyang Meng Yiya Kong Yi Li Chenguang Yang Ying Guo Xiqiang Wang Haini Yang Zhongwei Liu Fang Wang

Published in: Oxidative medicine and cellular longevity (2022)

Selenium supplementation showed cardioprotective effects on AGE-induced heart failure by suppressing ROS-mediated myocyte apoptosis. Selenium supplementation suppressed ROS generation by increasing GPX1 expression via inhibiting DNMT2-induced GPX1 gene promoter DNA methylation in myocytes exposed to AGEs.

Keyphrases

dna methylation
heart failure
genome wide
high glucose
gene expression
cell death
copy number
left ventricular
drug induced
endoplasmic reticulum stress
transcription factor
atrial fibrillation
signaling pathway
endothelial cells
cell proliferation
binding protein
cardiac resynchronization therapy