Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an In Vitro Inflammation Model in HepG2 Cells.

Katharina MörsRamona SturmJason-Alexander HöraufShinwan KanyPaola CavalliJazan OmariMaciej PowerskiAlexey SurovIngo MarziAleksander J Nowak Borna Relja

Published in: Disease markers (2021)

EtOH exerts anti-inflammatory potential in this in vitro model of hepatic inflammation. These effects are associated with the reduced activation of JNK/STAT3 by EtOH, particularly in the condition of acute exposure to low-dose EtOH.

Keyphrases

low dose
signaling pathway
oxidative stress
cell proliferation
anti inflammatory
induced apoptosis
cell death
liver failure
high dose
respiratory failure
drug induced
aortic dissection
climate change
hepatitis b virus
alcohol consumption
extracorporeal membrane oxygenation